1,3-Bis(hydroxymethyl)benzimidazolin-2-one
نویسندگان
چکیده
The title compound, C(9)H(10)N(2)O(3), crystallizes with one and a half mol-ecules in the asymmetric unit, one lying on a general position and the other on a twofold rotation axis. The dihedral angle between the two independent benzimidazole ring systems is 18.96 (5)°. In the crystal, mol-ecules are linked into a three-dimensional network by O-H⋯O hydrogen bonding involving N-hydroxy-methyl and carbonyl groups, and C-H⋯O hydrogen bonds.
منابع مشابه
5,5-Bis(hydroxymethyl)-2-phenyl-1,3-dioxane
In the title compound, C(12)H(16)O(4), the 1,3-dioxane ring adopts a chair conformation; the 2-phenyl substitutent occupies an equatorial position. Adjacent mol-ecules are linked by O-H⋯O hydrogen bonds into a chain.
متن کاملBis[μ-4-amino-3,5-bis(hydroxymethyl)-1,2,4-triazole]bis{bis[4-amino-3,5-bis(hydroxymethyl)-1,2,4-triazole]nickel(II)} tetranitrate methanol disolvate
The title complex, [Ni(2)(C(4)H(8)N(4)O(2))(6)](NO(3))(4)·2CH(4)O, contains a centrosymmetric binuclear nickel(II) complex bridged by a pair of 4-amino-3,5-bis-(hydroxy-meth-yl)-1,2,4-triazole ligands. The separation between the Ni(II) atoms is 3.962 (1) Å. The Ni atoms are in a slightly distorted octa-hedral coordination. Inter-molecular N-H⋯O, N-H⋯N and O-H⋯O hydrogen bonds connect the ligand...
متن کاملDiversity-oriented synthesis of 1-hydroxy-2,4-benzodioates by regioselective [3+3] cyclocondensations of 1,3-bis(silyloxy)-1,3-butadienes with 3-alkoxy- and 3-silyloxy-2-alkoxycarbonyl-2-en-1-ones.
1-Hydroxy-3,5-dimethyl-2,4-benzodioates (4-hydroxyisophthalates) were prepared by [3+3] cyclocondensation of 1,3-bis(silyloxy)-1,3-butadienes with 3-ethoxycarbonyl-4-trimethylsilyloxy-3-penten-2-one which is synthesized from (symmetrical) ethyl 2-acetylacetoacetate. The [3+3] cyclization of 1,3-bis(silyloxy)-1,3-butadienes with 3-alkoxy-2-alkoxycarbonyl-2-en-1-ones, readily available by reactio...
متن کاملSynthesis of 2,2′-(1,4-Phenylene)bis-3,4-dihydro-2H-1,3-thiazin-4-ones and their Facile Recyclization to 2,2′-(1,4-Phenylene)bis(pyrimidin-4-one) and/or 2,2′-(1,4-Phenylene)-bis-(thieno[2,3-d]pyrimidin-4(1H)-one) Derivatives
1,3-Thiazines are an important type of heterocycles showing a wide variety of pharmacological properties. Thus, 1,3-thiazine derivatives have recently been reported as cholecystokinin antagonists [1], antimycobacterial agents [2], cannabinoid receptor agonists [3], and inhibitors of NO synthase (NOS) [4], as antibacterial [5], antipyretic [6], anti-inflammatory [6, 7], analgesic [7], antitumor ...
متن کامل1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium 2,2-dichloroacetate
The title compound, C(4)H(12)NO(3) (+)·C(2)HCl(2)O(2) (-), was obtained from dichloro-acetic acid and 2-amino-2-(hydroxy-meth-yl)propane-1,3-diol. In the crystal structure, the cations and anions are connected by inter-molecular N-H⋯O and O-H⋯O hydrogen bonding, forming a two-dimensional array parallel to (001). The crystal used for analysis was a merohedral twin, as indicated by the Flack para...
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عنوان ژورنال:
دوره 65 شماره
صفحات -
تاریخ انتشار 2009